San Francisco 49ers 48, Indianapolis Colts 27 · Dec 23, 2025 · statshawk

NFLScores

football game fileFinal

San Francisco 49ersaway

48

at

Indianapolis Coltshome

27

Mon, Dec 22, 2025, 8:15 PM ESTLucas Oil Stadium · Indianapolis · USA

Comparison

Side by side.

Final

Away

San Francisco 49ers

Score

48

Home

Indianapolis Colts

Score

27

Key performers

Brock Purdy295 PASS YDS · 5 PASS TD Philip Rivers277 PASS YDS · 2 PASS TD